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Standard Practice for Use of Gel Filtration Columns for Cytotoxicity Reduction and Neutralization
Automaticky přeložený název:
Standardní praxe pro využívání gelovou filtrací kolony pro snížení cytotoxicity a jeho neutralizaci
NORMA vydána dne 1.10.2012
Označení normy: ASTM E1482-12
Poznámka: NEPLATNÁ
Datum vydání normy: 1.10.2012
Kód zboží: NS-41913
Počet stran: 3
Přibližná hmotnost: 9 g (0.02 liber)
Země: Americká technická norma
Kategorie: Technické normy ASTM
Dezinfekční a antiseptické prostředky
Chemikálie pro účely průmyslové a domácí dezinfekce
Keywords:
cytotoxicity, disinfectant, gel filtration, neutralization, tissue culture, virucidal, virucidal neutralization method, ICS Number Code 11.080.20 (Disinfectants and antiseptics), 71.100.35 (Chemicals for industrial and domestic desinfection purposes)
Significance and Use | ||||
4.1 This practice is to be used for the removal of virucidal agents from test product-virus mixtures, or from test product-neutralizer-virus mixtures, at or after the contact period and before the inoculation of these mixtures into host systems for assay of viral infectivity. 4.2 The purpose of the practice is to reduce the concentration of the cytotoxic properties of the test product and neutralizers in order to permit the evaluation of viral infectivity at dilutions that would otherwise be toxic to the host cells. 4.3 The practice is applicable to the testing of liquid, pre-saturated towelettes, and pressurized disinfectant products, as well as handwash/rub products. 4.4 This practice is compatible with
organic soil loads, hard water, disinfectants containing organic
solvents, and chemical neutralizers.
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1. Scope | ||||
1.1 This practice is intended to be
used to reduce the cytotoxic level of the virus-test product
mixture prior to assaying for viral infectivity. It is used in
conjunction with evaluations of the virucidal efficacy of
disinfectant solutions, wipes, trigger sprays, or pressurized
disinfectant spray products intended for use on inanimate,
nonporous environmental surfaces. This practice may also be used in
the evaluation of hygienic handwashes/handrubs, or for other
special applications. The practice may be employed with all viruses
and host systems.
1.2 This practice should be performed only by persons trained in virology techniques. 1.3 This practice utilizes gel filtration technology. The effectiveness of the practice is dependent on the ratio of gel bed volume to sample size and uniformity in the preparation of columns as well as the conditions of entrifugation. The effectiveness of this practice is maximized by investigator practice and experience with gel filtration techniques. 1.4 This practice will aid in the reduction, but not necessarily elimination, of test product toxicity while preserving the titer of the input virus. 1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.6 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. |
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2. Referenced Documents | ||||
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