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Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity
Automaticky přeložený název:
Standardní Guide for Performing na myších lymfomů pro savčích buněk Mutagenita
NORMA vydána dne 1.1.1997
Označení normy: ASTM E1280-97
Poznámka: NEPLATNÁ
Datum vydání normy: 1.1.1997
Kód zboží: NS-41125
Počet stran: 9
Přibližná hmotnost: 27 g (0.06 liber)
Země: Americká technická norma
Kategorie: Technické normy ASTM
Keywords:
Assay, Carcinogenicity, Chromosomal/genetic effects, Cloning, Cytotoxicity, Data analysis-environmental, Genetic examination, Mammalian cell mutagenicity, Metabolic activation, MLA (mouse lymphoma assay), Mouse/mice, Plating (cloning) efficiency, Quality control, Solubility, Spontaneous (background) mutant frequency, Test animals, Testing methods, THMG cleansing, Total growth, Toxicity/toxicology, performing the mouse lymphoma assay for mammalian cell mutagenicity,, guide
1. Scope |
1.1 The purpose and scope of this guide is to present background material and to establish criteria by which protocols and procedures for conducting the L5178Y/TK +/- 3.7.2C mouse lymphoma mutagenicity assay (commonly referred to as the mouse lymphoma assay, (MLA)) can be properly understood and evaluated. These guidelines are also intended to aid researchers and others to gain a better understanding of the critical elements involved with mammalian cell mutagenicity testing. More specifically, this guide is intended to provide for researchers the accomplishment of the following goals: 1.1.1 Provide an understanding of the critical procedures (steps) in the performance of this mammalian cell mutagenicity test. 1.1.2 Provide generalized criteria by which researchers can evaluate if they are properly performing, utilizing, and interpreting this assay. 1.1.3 Provide criteria by which individuals responsible for evaluating MLA data can determine if the experiments have been properly performed and interpreted. 1.1.4 Provide a basis from which new procedures and developments in testing procedures can be evaluated. 1.1.5 Provide an understanding of the types of genetic damage (that is, gene and chromosomal mutation) that may be detected in this mammalian cell mutagenicity test. |
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